Abstract Introduction Loeys-Dietz syndrome (LDS) is a connective tissue disorder that arises
from mutations altering the transforming growth factor β signalling pathway. Due to the …

The transforming growth factor-β (TGF-β) family of cytokines exerts pleiotropic functions
during embryonic development, tissue homeostasis and repair as well as within the immune …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Dysregulated transforming growth factor TGF-β signaling underlies the pathogenesis of
genetic disorders affecting the connective tissue such as Loeys-Dietz syndrome. Here, we …

The mechanisms that maintain intestinal homeostasis despite constant exposure of the gut
surface to multiple environmental antigens and to billions of microbes have been scrutinized …

Background and Aims Mutations in DNA mismatch repair (MMR) genes are causative in
Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR …

Rationale: Cryptogenic strokes, those of unknown cause, have been estimated as high as
30% to 40% of strokes. Inflammation has been suggested as a critical etiologic factor …

An integrated approach to diagnosis, risk analysis, and management can include diagnostic
approaches not often utilized for traditional IBD such as whole exome sequencing …

Abstract Purpose Loeys–Dietz syndrome (LDS) is a connective tissue disorder affecting
multiple organ systems, including bone. Methods We defined the bone phenotype and …

In Crohn's disease (CD) and ulcerative colitis (UC), the major inflammatory bowel diseases
(IBD) in human beings, the tissue-damaging inflammatory response is characterized by …