[HTML][HTML] Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment
Highlights•Management of tuberculosis is complicated by high levels of drug resistance in
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …
Drug-resistance in Mycobacterium tuberculosis: where we stand
A Mabhula, V Singh - Medchemcomm, 2019 - pubs.rsc.org
Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …
Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing
CRyPTIC Consortium and the 100,000 … - … England Journal of …, 2018 - Mass Medical Soc
Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …
Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study
NA Makhado, E Matabane, M Faccin… - The Lancet Infectious …, 2018 - thelancet.com
Background Global roll-out of rapid molecular assays is revolutionising the diagnosis of
rifampicin resistance, predictive of multidrug-resistance, in tuberculosis. However, 30% of …
rifampicin resistance, predictive of multidrug-resistance, in tuberculosis. However, 30% of …
Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a …
Background Bedaquiline and clofazimine are important drugs in the treatment of drug-
resistant tuberculosis and are commonly used across southern Africa, although drug …
resistant tuberculosis and are commonly used across southern Africa, although drug …
Evaluation of parameters affecting performance and reliability of machine learning-based antibiotic susceptibility testing from whole genome sequencing data
AL Hicks, N Wheeler, L Sánchez-Busó… - PLoS computational …, 2019 - journals.plos.org
Prediction of antibiotic resistance phenotypes from whole genome sequencing data by
machine learning methods has been proposed as a promising platform for the development …
machine learning methods has been proposed as a promising platform for the development …
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene …
Nature communications, 2024 - nature.com
Abstract The World Health Organization has a goal of universal drug susceptibility testing for
patients with tuberculosis. However, molecular diagnostics to date have focused largely on …
patients with tuberculosis. However, molecular diagnostics to date have focused largely on …
Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences
Background Mycobacterium tuberculosis whole genome sequencing (WGS) data can
provide insights into temporal and geographical trends in resistance acquisition and inform …
provide insights into temporal and geographical trends in resistance acquisition and inform …
Rapid molecular assays for detection of tuberculosis
R Eddabra, H Ait Benhassou - Pneumonia, 2018 - Springer
Tuberculosis (TB) is an infectious disease that remains an important public health problem
at the global level. It is one of the main causes of morbidity and mortality, due to the …
at the global level. It is one of the main causes of morbidity and mortality, due to the …
Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of …
NM Al-Mutairi, S Ahmad, E Mokaddas, HS Eldeen… - BMC infectious …, 2019 - Springer
Background Accurate drug susceptibility testing (DST) of Mycobacterium tuberculosis in
clinical specimens and culture isolates to first-line drugs is crucial for diagnosis and …
clinical specimens and culture isolates to first-line drugs is crucial for diagnosis and …