Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Background Legionella pneumophila, Mycobacterium avium, and Pseudomonas
aeruginosa are opportunistic premise plumbing pathogens (OPPPs) that persist and grow in …

Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia
and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid …

Immune surveillance by T helper type 1 (TH1) cells is not only critical for the host response
to tumors and infection, but also contributes to autoimmunity and graft-versus-host disease …

During gaseous exchange the lungs are exposed to a vast variety of pathogens, allergens,
and innocuous particles. A feature of the lung immune response to lung-tropic aerosol …

Non-tuberculous mycobacteria cause a broad range of clinical disorders, from cutaneous
infections, such as cervical or intrathoracic lymphadenitis in children, to disseminated …

We identified 18 patients with the distinct clinical phenotype of susceptibility to disseminated
nontuberculous mycobacterial infections, viral infections, especially with human …

Th1 lymphocytes are crucial in the immune response against Mycobacterium tuberculosis.
Nevertheless, IFN-γ alone is not sufficient in the complete eradication of the bacteria …

OBJECTIVE To determine the incidence and temporal trends of primary immunodeficiency
diseases (PIDs) and examine whether an association exists between delayed diagnosis and …

Background DNA vaccines are a promising approach to vaccination since they circumvent
the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown …