Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors
that regulate lipid and energy metabolism. The brain–gut–liver axis plays an essential role in …

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …

Background Progressive familial intrahepatic cholestasis (PFIC) is a group of inherited
paediatric liver diseases resulting from mutations in genes that impact bile secretion. We …

The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism
through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and …

The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile
acid metabolism and signaling. Activation of FXR inhibits bile acid synthesis and increases …

Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP)
enzymes play key roles in bile acid synthesis. Bile acids are physiological detergent …

Cholestasis is a condition characterized by the abnormal production or excretion of bile, and
it can be induced by a variety of causes, the factors of which are extremely complex …

Cholestasis is a clinical condition resulting from the imapairment of bile flow. This condition
could be caused by defects of the hepatocytes, which are responsible for the complex …

Background and aims Progressive familial intrahepatic cholestasis (PFIC) is a
heterogeneous group of rare genetic disorders associated with bile acid secretion or …