Central nervous system (CNS) homeostasis critically depends on the interaction between
neurons and glia cells. Extracellular vesicles (EVs) recently emerged as versatile …

Autosomal recessive primary microcephaly (MCPH) is a constellation of disorders that share
significant brain size reduction and mild to moderate intellectual disability, which may be …

INTRODUCTION In response to aging, senescence plays a major role in the onset of various
degenerative diseases, including the slow development of cataracts, a clouding of the eye …

Tcf4 has been linked to autism, schizophrenia, and Pitt-Hopkins Syndrome (PTHS) in
humans, suggesting a role for Tcf4 in brain development and importantly cortical …

In mammalian cell lines, the endosomal sorting complex required for transport (ESCRT)-III
mediates abscission, the process that physically separates daughter cells and completes …

Monoubiquitination of proteins governs diverse physiological processes, and its
dysregulation is implicated in multiple pathologies. The difficulty of preparing sufficient …

Abscission, the final step of cytokinesis, cleaves the thin intercellular bridge connecting the
two daughter cells [1–6]. The scaffold protein ALIX is a core component of the abscission …

Background The functions and protein expressions of the blood–brain barrier are changed
throughout brain development following birth. This study aimed to develop a method to …

In chemical synapses undergoing high frequency stimulation, vesicle components can be
retrieved from the plasma membrane via a clathrin-independent process called activity …

The endosomal sorting complex required for transport (ESCRT) is made of subcomplexes
(ESCRT 0-III), crucial to membrane remodelling at endosomes, nuclear envelope and cell …