Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …

LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of
cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific …

Deubiquitinating enzymes (DUBs) are a group of proteases that are important for
maintaining cell homeostasis by regulating the balance between ubiquitination and …

Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that
eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of …

As an important form of posttranslational modification, protein ubiquitination regulates a
wide variety of biological processes, including different aspects of T cell development and …

Abstract Fms‐like tyrosine kinase‐3 (FLT3) is a commonly mutated gene in acute myeloid
leukemia (AML). The two most common mutations are the internal‐tandem duplication …

The K63-linkage specific deubiquitinase BRCC36 forms the core of two multi-subunit
deubiquitination complexes: BRCA1-A and BRISC. BRCA1-A is recruited to DNA repair foci …

Thrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major
cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl …

BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked
with inflammatory processes, but its role in liver diseases and the underlying mechanism are …

Abstract BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific
deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and …