Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases
B Estavoyer, C Messmer, M Echbicheb… - Journal of Biological …, 2022 - ASBMB
Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …
The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis
LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of
cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific …
cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific …
Structural and functional basis of JAMM deubiquitinating enzymes in disease
X Pan, S Wu, W Wei, Z Chen, Y Wu, K Gong - Biomolecules, 2022 - mdpi.com
Deubiquitinating enzymes (DUBs) are a group of proteases that are important for
maintaining cell homeostasis by regulating the balance between ubiquitination and …
maintaining cell homeostasis by regulating the balance between ubiquitination and …
Deubiquitinases in cell death and inflammation
K Newton, AD Gitlin - Biochemical Journal, 2022 - portlandpress.com
Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that
eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of …
eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of …
Protein ubiquitination in T cell development
T Zhong, K Lei, X Lin, Z Xie, S Luo, Z Zhou… - Frontiers in …, 2022 - frontiersin.org
As an important form of posttranslational modification, protein ubiquitination regulates a
wide variety of biological processes, including different aspects of T cell development and …
wide variety of biological processes, including different aspects of T cell development and …
BRCC36 associates with FLT3‐ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia
J Liu, T Isaji, S Komatsu, Y Sun, X Xu, T Fukuda… - Cancer …, 2024 - Wiley Online Library
Abstract Fms‐like tyrosine kinase‐3 (FLT3) is a commonly mutated gene in acute myeloid
leukemia (AML). The two most common mutations are the internal‐tandem duplication …
leukemia (AML). The two most common mutations are the internal‐tandem duplication …
BRCA1-A and BRISC: multifunctional molecular machines for ubiquitin signaling
J Rabl - Biomolecules, 2020 - mdpi.com
The K63-linkage specific deubiquitinase BRCC36 forms the core of two multi-subunit
deubiquitination complexes: BRCA1-A and BRISC. BRCA1-A is recruited to DNA repair foci …
deubiquitination complexes: BRCA1-A and BRISC. BRCA1-A is recruited to DNA repair foci …
Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease
Thrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major
cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl …
cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl …
BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury
W Zhang, K Liu, GM Ren, Y Wang, T Wang, X Liu… - Cell Death & …, 2023 - nature.com
BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked
with inflammatory processes, but its role in liver diseases and the underlying mechanism are …
with inflammatory processes, but its role in liver diseases and the underlying mechanism are …
Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)
T Meyer, N Jahn, S Lindner, L Röhner, A Dolnik… - Leukemia, 2020 - nature.com
Abstract BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific
deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and …
deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and …