Nervous system processes, including cognition and affective state, fundamentally rely on
mitochondria. Impaired mitochondrial function is evident in major depressive disorder …

Aging is a natural process, characterized by progressive loss of physiological integrity,
impaired function, and increased vulnerability to death. For centuries, people have been …

Mitochondria-nuclear coadaptation has been central to eukaryotic evolution. The dynamic
dialogue between the two compartments within the context of multiorganellar interactions is …

Low levels of mitochondrial stress are beneficial for organismal health and survival through
a process known as mitohormesis. Mitohormetic responses occur during or after exercise …

Pancreatic β cells dedicate much of their protein translation capacity to producing insulin to
maintain glucose homeostasis. In response to increased secretory demand, β cells can …

Parkinson's disease (PD) is the second most common rapidly progressive
neurodegenerative disease and has serious health and socio-economic consequences …

Nonalcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of
fat in the liver, is estimated to be the most common liver disease worldwide. Obesity is a …

Maintaining mitochondrial function is critical to an improved healthspan and lifespan.
Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial …

Increase in body fat contributes to loss of function and changes in skeletal muscle,
accelerating sarcopenia, a phenomenon known as sarco-obesity or sarcopenic obesity …

Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative disease and the
most common cause of dementia among older adults. There are no effective treatments …