Small dataset solves big problem: An outlier-insensitive binary classifier for inhibitory potency prediction

T Zhou, H Dou, J Tan, Y Song, F Wang… - Knowledge-Based Systems, 2022 - Elsevier
Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors show importance in cancer
disease treatment while selecting compounds from a library according to inhibitory potency …

A multi-view multi-omics model for cancer drug response prediction

Z Wang, Z Wang, Y Huang, L Lu, Y Fu - Applied Intelligence, 2022 - Springer
Cancer drug response prediction is the fundamental task in precision medicine, which
provides opportunities for cancer therapy. Several methods have been proposed to screen …

Integrating Multi-Omics Using Bayesian Ridge Regression with Iterative Similarity Bagging

TM Almutiri, KH Alomar, NA Alganmi - Applied Sciences, 2024 - mdpi.com
Cancer research has increasingly utilized multi-omics analysis in recent decades to obtain
biomolecular information from multiple layers, thereby gaining a better understanding of …

Interval type-2 enhanced possibilistic fuzzy c-means clustering for gene expression data analysis

S Sotudian, MHF Zarandi - arXiv preprint arXiv:2101.00304, 2021 - arxiv.org
Both FCM and PCM clustering methods have been widely applied to pattern recognition and
data clustering. Nevertheless, FCM is sensitive to noise and PCM occasionally generates …

Multi-Cohort Transcriptomic Profiling of Medical Gas Plasma-Treated Cancers Reveals the Role of Immunogenic Cell Death

A Gkantaras, C Kotzamanidis, K Kyriakidis, E Farmaki… - Cancers, 2024 - mdpi.com
Simple Summary Medical gas plasma is a new modality in cancer treatment showing
favorable results in preclinical and clinical trials; however, the cascade of molecular events …

SAFE-MIL: a statistically interpretable framework for screening potential targeted therapy patients based on risk estimation

Y Guan, Z Xue, J Wang, X Ai, R Chen, X Yi, S Lu… - Frontiers in …, 2024 - frontiersin.org
Patients with the target gene mutation frequently derive significant clinical benefits from
target therapy. However, differences in the abundance level of mutations among patients …

Distributionally robust learning-to-rank under the Wasserstein metric

S Sotudian, R Chen, IC Paschalidis - PloS one, 2023 - journals.plos.org
Despite their satisfactory performance, most existing listwise Learning-To-Rank (LTR)
models do not consider the crucial issue of robustness. A data set can be contaminated in …

Social determinants of health and the prediction of missed breast imaging appointments

S Sotudian, A Afran, CA LeBedis, AF Rives… - BMC Health Services …, 2022 - Springer
Background Predictive models utilizing social determinants of health (SDH), demographic
data, and local weather data were trained to predict missed imaging appointments (MIA) …

ITNR: Inversion Transformer-based Neural Ranking for cancer drug recommendations

S Sotudian, IC Paschalidis - Computers in Biology and Medicine, 2024 - Elsevier
Personalized drug response prediction is an approach for tailoring effective therapeutic
strategies for patients based on their tumors' genomic characterization. While machine …

Distributionally robust multi-output regression ranking

S Sotudian, R Chen, I Paschalidis - arXiv preprint arXiv:2109.12803, 2021 - arxiv.org
Despite their empirical success, most existing listwiselearning-to-rank (LTR) models are not
built to be robust to errors in labeling or annotation, distributional data shift, or adversarial …