Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

Background: Cancer stem cells (CSCs) are highly tumorigenic, chemotherapy-resistant,
tumor growth-sustaining, and are implicated in tumor recurrence. Previous studies have …

TAR-DNA-binding protein-43 (TDP-43) is a member of hnRNP family and acts as both RNA
and DNA binding regulator, mediating RNA metabolism and transcription regulation in …

Background & aims Intrahepatic cholangiocarcinoma (iCCA) is a fatal malignancy of the
biliary system. The lack of a detailed understanding of oncogenic signaling or global gene …

Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been
implicated in the tumorigenesis of different cancer types. However, the functional roles of …

Numerous studies have demonstrated an inverse link between cancer and Alzheimer's
disease (AD), with data suggesting that people with Alzheimer's have a decreased risk of …

Simple Summary Anaplastic thyroid carcinoma (ATC) is a biological aggressive human
carcinoma and causes most of the thyroid cancer related deaths. Non-protein producing …

Anaplastic thyroid carcinoma (ATC) is an extremely aggressive tumor with a high mortality
rate and poor prognosis. However, the pathogenesis of ATC is complex and poorly …

The anti-tumor effect of polo-like kinase 4 (PLK4) inhibitor has been explored in several
solid carcinomas, while its application in anaplastic thyroid cancer (ATC) remains scarce …

Abstract Context microRNA (miR/miRNA)-144-3p has been implicated in thyroid cancer (TC)
progression with poorly identified mechanisms. Furthermore, E2F2 has been documented to …