Background There is an extensive literature highlighting the utility of blood-based liquid
biopsies in several extracranial tumors for diagnosis and monitoring. Methods The RANO …

Purpose of review This review of diffuse intrinsic pontine glioma (DIPG) provides clinical
background, a systematic approach to diagnosis and initial care, and synthesizes historical …

BACKGROUND Patients with diffuse midline gliomas (DMGs), including diffuse intrinsic
pontine glioma (DIPG), have dismal outcomes. We previously described the H3. 3K27M …

Purpose: PNOC003 is a multicenter precision medicine trial for children and young adults
with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Patients and Methods: Patients …

This clinical trial evaluated whether whole exome sequencing (WES) and RNA sequencing
(RNAseq) of paired normal and tumor tissues could be incorporated into a personalized …

Diffuse midline gliomas harboring the H3 K27M mutation—including the previously named
diffuse intrinsic pontine glioma (DIPG)—are lethal high-grade pediatric brain tumors that are …

Optimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of
consistent, objective disease assessments and standardised response criteria. The …

Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of
pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall …

Abstract Background Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine
gliomas (DIPGs), have a dismal prognosis, with less than 2% surviving 5 years …

Diffuse intrinsic pontine glioma (DIPG) is a type of intrinsic brainstem glial tumor that occurs
primarily in the pediatric population. DIPG is initially diagnosed based on clinical symptoms …