Atherosclerosis is now widely recognized as a chronic inflammatory disease that involves
innate and adaptive immune responses. Both cellular and humoral components of the …

Cardiovascular disease (CVD) is generally accepted as the leading cause of morbidity and
mortality worldwide, and an increasing number of patients suffer from atherosclerosis and …

Background We have previously defined mechanisms of intimal hyperplasia that could be
targets for molecular therapeutics aimed at vascular pathology. However, biocompatible …

Professional athletes are often exposed to high training loads that may lead to overfatigue,
overreaching and overtraining that might have a detrimental effects on vascular health. We …

Background Androgen deficiency (AD) is associated with increased risk of atherosclerosis,
cardiovascular, and peripheral arterial disease. Although the biochemical and molecular …

While androgen is considered a pivotal regulator of sexually dimorphic development, it
remains unclear how it orchestrates the differentiation of reproductive organs. Using external …

Colorectal cancer (CRC) is the third most common cause of cancer mortality worldwide and
the most prevalent cancer in Taiwan. The matrix metalloproteinase (MMP)-11 is a proteolytic …

Mounting evidence suggests that the phenotypic transformation of venous smooth muscle
cells (SMCs) from differentiated (contractile) to dedifferentiated (proliferative and migratory) …

Matrix metalloproteinases (MMPs) play an important role during physiological tissue
remodeling in embryonic development and angiogenesis, as well as in pathophysiological …

Fragmentation/loss of the structural protein elastin represents the precipitating event
translating to aortic expansion and subsequent aneurysm formation. The present study …