Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and
detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

Dopamine neurons of the substantia nigra and ventral tegmental area regulate movement
and affective behavior and degenerate in Parkinson's disease. The orphan nuclear receptor …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

The prospect of using cell replacement therapies has raised the key issue of whether
elucidation of developmental pathways can facilitate the generation of therapeutically …

The nuclear hormone receptor (NR) superfamily includes the orphan NR4A subgroup,
comprised of Nur77 (NR4A1), Nurr1 (NR4A2) and NOR-1 (NR4A3). These NRs are …

Numerous members of the nuclear hormone receptor (NR) superfamily have been
demonstrated to regulate metabolic function in a cell-and tissue-specific manner. This …

The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli,
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …

The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …

Members of the nuclear hormone receptor superfamily, including the peroxisome proliferator–
activated receptor and the liver X receptor subfamilies, orchestrate transcriptional networks …