Dopamine receptors: molecular biology, biochemistry and behavioural aspects

DM Jackson, A Westlind-Danielsson - Pharmacology & therapeutics, 1994 - Elsevier
The description of new dopamine (DA) receptor subtypes, D1-(D1 and D5) and D2-like
(D2A, D2B, D3, D4), has given an impetus to DA research. While selective agonists and …

Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae

RKW Schwarting, JP Huston - Progress in neurobiology, 1996 - Elsevier
One of the primary approaches in experimental brain research is to investigate the effects of
specific destruction of its parts. Here, several neurotoxins are available which can be used to …

Developmental and age-related changes in D1-dopamine receptors and dopamine content in the rat striatum

O Giorgi, G De Montis, ML Porceddu, S Mele… - Developmental Brain …, 1987 - Elsevier
The relationship between the postnatal development of dopaminergic (DAergic) nerve
endings and the maturation of D 1 DA receptors in the rat striatum was analyzed by …

Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats

K Berger, S Przedborski, JL Cadet - Brain research bulletin, 1991 - Elsevier
Quantitative receptor autoradiography was used to assess the effects of unilateral
intrastriatal injections of 6-hydroxydopamine (6-OHDA) on the distribution of D1 and D2 …

Continuous and intermittent levodopa differentially affect basal ganglia function

JL Juncos, TM Engber, R Raisman… - Annals of Neurology …, 1989 - Wiley Online Library
The effects of continuous and intermittent levodopa treatment on behavioral and
biochemical indexes of basal ganglia function were compared in rats with unilateral 6 …

Selective localization of striatal D1 receptors to striatonigral neurons

MB Harrison, RG Wiley, GF Wooten - Brain research, 1990 - Elsevier
A new technique for producing anatomically selective lesions within the brain was used to
investigate the cellular localization of the D 1 and D 2 receptor. The cytotoxic lectin …

Drugs acting on brain dopamine receptors: a conceptual re-evaluation five years after the first selective D-1 antagonist

JL Waddington, KM O'Boyle - Pharmacology & therapeutics, 1989 - Elsevier
Science usually advances through a combination of small but cumulative increments in
knowledge, often painstakingly obtained, and interpolations of dramatic'quantum'leaps …

Decreased striatal D1 binding density following mesotelencephalic 6-hydroxydopamine injections: an autoradiographic analysis

JF Marshall, R Navarrete, JN Joyce - Brain research, 1989 - Elsevier
Autoradiographic experiments performed on rats with unilateral mesotelencephalic 6-
hydroxydopamine (6-OHDA) injections revealed reduced binding of [3 H] SCH23390 to D 1 …

Synthesis and release of dopamine in rat brain: comparison between substantia nigra pars compacta, pars reticulata, and striatum

H Nissbrandt, E Sundström, G Jonsson… - Journal of …, 1989 - Wiley Online Library
Dopamine (DA) is synthesized and released not only from the terminals of the nigrostriatal
dopaminergic neuronal pathway, but also from the dendrites in the substantia nigra. We …

Association of dopamine d, and d2 receptors with specific cellular elements in the basal ganglia of the cat: The uneven topography of dopamine receptors in the …

RM Beckstead - Neuroscience, 1988 - Elsevier
To ascertain the cellular associations of the D 1 and D 2 dopamine receptor subtypes in
components of the basal ganglia, cats were prepared with unilateral, axon-sparing, ibotenic …