We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

It is known that newer antidepressants, such as the selective serotonin reuptake inhibitors
(SSRIs), provide advantages in tolerability over antidepressants such as the tricyclics …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

Current management of major depression, a common and debilitating disorder with a high
social and personal cost, is far from satisfactory. All available antidepressants act through …

BACKGROUND: In 2001, the Canadian Psychiatric Association and the Canadian Network
for Mood and Anxiety Treatments (CANMAT) partnered to produce evidence-based clinical …

Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

Objectives. These guidelines are based on a first edition that was published in 2002, and
have been edited and updated with the available scientific evidence until September 2009 …

Abstract Treatment resistance to the antidepressive pharmacotherapy represents one of the
most important clinical challenges in the pharmacological management of unipolar …

Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-
based antidepressants were the first drugs developed to treat major depressive disorder …

Modern neuropsychopharmacology commenced in the 1950s with the serendipitous
discovery of first-generation antipsychotics and antidepressants which were therapeutically …