5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous
system and peripheral structures, acting also as a hormone in platelets. Although its …

Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are
mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family …

Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

Serotonin (5-HT) induces concentration-dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta-cells, fibroblasts …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Serotoninergic neurons in the central nervous system impinge on many other neurons and
modulate their neurotransmitter release. This review focuses on 1) the function of …

The human cardiovascular system is exposed to plasma 5-hydroxytryptamine (5-HT,
serotonin), usually released from platelets. 5-HT can produce harmful acute and chronic …

The 5-hydroxytryptamine type-3 (5-HT3) receptor is a cation-selective ion channel of the Cys-
loop superfamily. 5-HT3 receptor activation in the central and peripheral nervous systems …