Overcoming the challenges of infrared photosensitizers in photodynamic therapy: The making of redaporfin

LG Arnaut, MM Pereira - Chemical Communications, 2023 - pubs.rsc.org
We offer a personal account of the discovery and development of a photosensitizer for
photodynamic therapy (PDT) of cancer, from bench to bedside. We emphasize the more …

Modifications of porphyrins and hydroporphyrins for their solubilization in aqueous media

M Luciano, C Brückner - Molecules, 2017 - mdpi.com
The increasing popularity of porphyrins and hydroporphyrins for use in a variety of
biomedical (photodynamic therapy, fluorescence tagging and imaging, photoacoustic …

Mechanisms of singlet‐oxygen and superoxide‐ion generation by porphyrins and bacteriochlorins and their implications in photodynamic therapy

EFF Silva, C Serpa, JM Dąbrowski… - … A European Journal, 2010 - Wiley Online Library
New halogenated and sulfonated bacteriochlorins and their analogous porphyrins are
employed as photosensitizers of singlet oxygen and the superoxide ion. The mechanisms of …

Antibacterial photodynamic inactivation of antibiotic-resistant bacteria and biofilms with nanomolar photosensitizer concentrations

CS Vinagreiro, A Zangirolami, FA Schaberle… - ACS infectious …, 2020 - ACS Publications
Gram-negative bacteria and bacteria in biofilms are very difficult to eradicate and are the
most antibiotic-resistant bacteria. Therapeutic alternatives less susceptible to mechanisms of …

Photodynamic therapy efficacy enhanced by dynamics: the role of charge transfer and photostability in the selection of photosensitizers

LG Arnaut, MM Pereira, JM Dąbrowski… - … A European Journal, 2014 - Wiley Online Library
Progress in the photodynamic therapy (PDT) of cancer should benefit from a rationale to
predict the most efficient of a series of photosensitizers that strongly absorb light in the …

Better in the near infrared: sulfonamide perfluorinated-phenyl photosensitizers for improved simultaneous targeted photodynamic therapy and real-time fluorescence …

M Warszyńska, B Pucelik, CS Vinagreiro… - … Applied Materials & …, 2024 - ACS Publications
Tetraphenyloporphyrin derivatives are a useful scaffold for developing new pharmaceuticals
for photodynamic therapy (PDT) and the photodiagnosis (PD) of cancer. We synthesized …

Improving singlet oxygen resistance during photochemical water oxidation by cobalt porphyrin catalysts

T Nakazono, AR Parent, K Sakai - Chemistry–A European …, 2015 - Wiley Online Library
Enabling the production of solar fuels on a global scale through artificial photosynthesis
requires the development of water oxidation catalysts with significantly improved stability …

[HTML][HTML] Fluorinated porphyrinoids and their biomedical applications

T Goslinski, J Piskorz - Journal of Photochemistry and Photobiology C …, 2011 - Elsevier
Porphyrins, phthalocyanines, chlorins and corroles create a compact group of macrocyclic
compounds of established utility in medicine and technology. Fluorine atom insertion to their …

Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies

B Pucelik, R Paczyński, G Dubin, MM Pereira… - PLoS …, 2017 - journals.plos.org
The impact of substituents on the photochemical and biological properties of
tetraphenylporphyrin-based photosensitizers for photodynamic therapy of cancer (PDT) as …

Mitochondria and DNA Targeting of 5,10,15,20-Tetrakis(7-sulfonatobenzo[b]thiophene) Porphyrin-Induced Photodynamic Therapy via Intrinsic and Extrinsic Apoptotic …

S Rangasamy, H Ju, S Um, DC Oh… - Journal of medicinal …, 2015 - ACS Publications
Photodynamic therapy (PDT) selectively targets subcellular organelles and promises an
excellent therapeutic strategy for cancer treatment. Here, we report the synthesis of a new …