Regular keratinocyte differentiation is crucial for the formation of an intact epidermal barrier
and is triggered by extracellular calcium. Disturbances of epidermal barrier formation and …

Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to
plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations …

Transient receptor potential vanilloid channel 3 (TRPV3), a member of the thermosensitive
TRP (thermoTRPV) channels, is activated by warm temperatures and serves as a key …

Olmsted syndrome (OS) is a rare genodermatosis classically characterized by the
combination of bilateral mutilating transgredient palmoplantar keratoderma (PPK) and …

Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP (Transient Receptor
Potential) super-family. It is a relatively underexplored member of the thermo-TRP sub …

Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series
of dermatologic diseases. A large variety of biological events and bioactive molecules are …

Transient receptor potential vanilloid 3 (TRPV3), robustly expressed in the skin, is a
nonselective calcium-permeable cation channel activated by warm temperature, voltage …

TRPV3 is a non-selective cation channel that is highly expressed in keratinocytes in the skin.
Traditionally, keratinocytes-expressed TRPV3 is involved in multiple physiological and …

Olmsted syndrome (OS) is a rare keratinization disorder, typically characterized by two
primary diagnostic hallmarks—mutilating palmoplanter and periorificial keratoderma …

Congenita Project for the evaluation of painful plantar keratoderma, but lacking
pseudoainhum or significant periorificial keratoderma. In each case, after no mutations were …