Heterogeneous Microfluidic Reactors: A Review and an Insight of Enzymatic Reactions

FWM Ling, HA Abdulbari, SY Chin - ChemBioEng Reviews, 2022 - Wiley Online Library
Heterogeneous reactions are considered the heart of chemical synthesis with numerous
industrial applications due to their high conversion rates and low reaction time. On the other …

[HTML][HTML] Flow synthesis kinetics for lomustine, an anti-cancer active pharmaceutical ingredient

S Diab, M Raiyat, DI Gerogiorgis - Reaction Chemistry & Engineering, 2021 - pubs.rsc.org
Continuous flow synthesis of active pharmaceutical ingredients (APIs) can offer access to
process conditions that are otherwise hazardous when operated in batch mode, resulting in …

Synthesis of Lobeglitazone intermediates seeking for continuous drug production in flow capillary microreactor

RR de Oliveira Silva, PVC Calvo, CA Merfels… - Journal of Industrial and …, 2022 - Elsevier
Continuous flow synthesis in microreactors has been integrated into chemical-
pharmaceutical industry in recent years as an alternative to the batch process due to its …

Residence time distribution of a capillary microreactor used for pharmaceutical synthesis

ÉS Siguemoto, L Leite Reche, JAW Gut… - Chemical …, 2020 - Wiley Online Library
The main drivers for application of small‐scale reactors in the pharmaceutical industry are
the possibility of rapid synthesis and screening of novel drugs as well as the readiness of the …

Process intensification in flow chemistry using micro and millidevices: Numerical simulations of the syntheses of three different intermediate API compounds for …

JL Silva Jr, PVC Calvo, MSA Palma, MGM Lopes… - … Research and Design, 2024 - Elsevier
Microreactor Technology (MRT) appears as an interesting alternative for process
intensification, including the development of continuous synthesis of fine chemicals and …

Flow Synthesis of 2‐[Methyl (pyridin‐2‐yl) amino] ethanol: An Experimental and Computational Study

PV Cuesta Calvo, P Rodrigues Batista… - Chemical …, 2021 - Wiley Online Library
Microreactor technology is increasingly applied in the chemical‐pharmaceutical industry for
safer and more efficient drug production as compared to the traditional batch process. This …

A hepatic sinusoids-based microtube reactor for (Z)-5-(4-hydroxybenzylidene) thiazolidine-2, 4-dione intermediate drug synthesis

MA Shouman, AH El-Shazly, MF Elkady… - Chemical Engineering …, 2022 - Elsevier
Microreactor technology is considered a breakthrough technology that can replace regular
reactors systems as microreactors deliver proper mixing and reaction performance which …

Application of Continuous‐Flow Processing in Multistep API and Drug Syntheses

FM Akwi, P Watts - Flow and Microreactor Technology in …, 2022 - Wiley Online Library
The use of flexible and cost‐effective manufacturing technologies for the production of active
pharmaceutical intermediates (APIs) is one major pathway toward solving drug shortage …

Síntese da Pioglitazona e Lobeglitazona em batelada e microrreator capilar

RRO Silva - 2023 - teses.usp.br
Síntese em fluxo em microrreatores é uma alternativa ao processo em batelada e vem
sendo incorporada à indústria químico-farmacêutica nos últimos anos devido às suas …

[PDF][PDF] Síntese do fármaco pioglitazona

PA Meira, RRO Silva, MSA Palma - … : pesquisas emergentes em …, 2022 - repositorio.usp.br
Objetivo: O presente trabalho teve como objetivo a realização de todas as etapas da síntese
do fármaco Pioglitazona em batelada e a transposição de uma das etapas para fluxo …