Small-angle X-ray scattering from RNA, proteins, and protein complexes
Small-angle X-ray scattering (SAXS) is increasingly used to characterize the structure and
interactions of biological macromolecules and their complexes in solution. Although still a …
interactions of biological macromolecules and their complexes in solution. Although still a …
RNA folding: thermodynamic and molecular descriptions of the roles of ions
DE Draper - Biophysical journal, 2008 - cell.com
The stability of a compact RNA tertiary structure is exquisitely sensitive to the concentrations
and types of ions that are present. This review discusses the progress that has been made in …
and types of ions that are present. This review discusses the progress that has been made in …
Bridging the gap between in vitro and in vivo RNA folding
Deciphering the folding pathways and predicting the structures of complex three-
dimensional biomolecules is central to elucidating biological function. RNA is single …
dimensional biomolecules is central to elucidating biological function. RNA is single …
General strategies for RNA X-ray crystallography
RW Jackson, CM Smathers, AR Robart - Molecules, 2023 - mdpi.com
An extremely small proportion of the X-ray crystal structures deposited in the Protein Data
Bank are of RNA or RNA–protein complexes. This is due to three main obstacles to the …
Bank are of RNA or RNA–protein complexes. This is due to three main obstacles to the …
Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch
N Kulshina, NJ Baird, AR Ferré-D'Amaré - Nature structural & molecular …, 2009 - nature.com
Abstract The cyclic diguanylate (bis-(3′-5′)-cyclic dimeric guanosine monophosphate, c-
di-GMP) riboswitch is the first known example of a gene-regulatory RNA that binds a second …
di-GMP) riboswitch is the first known example of a gene-regulatory RNA that binds a second …
Atomic level architecture of group I introns revealed
Twenty-two years after their discovery as ribozymes, the self-splicing group I introns are
finally disclosing their architecture at the atomic level. The crystal structures of three group I …
finally disclosing their architecture at the atomic level. The crystal structures of three group I …
[HTML][HTML] RNA misfolding and the action of chaperones
R Russell - Frontiers in bioscience: a journal and virtual library, 2008 - ncbi.nlm.nih.gov
RNA folds to a myriad of three-dimensional structures and performs an equally diverse set of
functions. The ability of RNA to fold and function in vivo is all the more remarkable because …
functions. The ability of RNA to fold and function in vivo is all the more remarkable because …
Time-resolved RNA SHAPE chemistry: quantitative RNA structure analysis in one-second snapshots and at single-nucleotide resolution
SA Mortimer, KM Weeks - Nature protocols, 2009 - nature.com
RNA selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemistry
exploits the discovery that conformationally dynamic nucleotides preferentially adopt …
exploits the discovery that conformationally dynamic nucleotides preferentially adopt …
An RNA folding motif: GNRA tetraloop–receptor interactions
JL Fiore, DJ Nesbitt - Quarterly reviews of biophysics, 2013 - cambridge.org
Nearly two decades after Westhof and Michel first proposed that RNA tetraloops may interact
with distal helices, tetraloop–receptor interactions have been recognized as ubiquitous …
with distal helices, tetraloop–receptor interactions have been recognized as ubiquitous …
[HTML][HTML] Cooperative tertiary interaction network guides RNA folding
R Behrouzi, JH Roh, D Kilburn, RM Briber… - Cell, 2012 - cell.com
Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To
understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we …
understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we …