Small-angle X-ray scattering (SAXS) is increasingly used to characterize the structure and
interactions of biological macromolecules and their complexes in solution. Although still a …

The stability of a compact RNA tertiary structure is exquisitely sensitive to the concentrations
and types of ions that are present. This review discusses the progress that has been made in …

Deciphering the folding pathways and predicting the structures of complex three-
dimensional biomolecules is central to elucidating biological function. RNA is single …

An extremely small proportion of the X-ray crystal structures deposited in the Protein Data
Bank are of RNA or RNA–protein complexes. This is due to three main obstacles to the …

Abstract The cyclic diguanylate (bis-(3′-5′)-cyclic dimeric guanosine monophosphate, c-
di-GMP) riboswitch is the first known example of a gene-regulatory RNA that binds a second …

Twenty-two years after their discovery as ribozymes, the self-splicing group I introns are
finally disclosing their architecture at the atomic level. The crystal structures of three group I …

RNA folds to a myriad of three-dimensional structures and performs an equally diverse set of
functions. The ability of RNA to fold and function in vivo is all the more remarkable because …

RNA selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemistry
exploits the discovery that conformationally dynamic nucleotides preferentially adopt …

Nearly two decades after Westhof and Michel first proposed that RNA tetraloops may interact
with distal helices, tetraloop–receptor interactions have been recognized as ubiquitous …

Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To
understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we …