Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Besides cardiomyocytes (CM), the heart contains numerous interstitial cell types which play
key roles in heart repair, regeneration and disease, including fibroblast, vascular and …

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate
acute wound healing and long-term tissue remodeling with scarring. With myocardial …

In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer
progresses, an accompanying host stromal response evolves within and around the nascent …

The effects of autonomic innervation of tumors on tumor growth remain unclear. Here we
developed a series of genetic techniques to manipulate autonomic innervation in a tumor …

The myocardium behaves like a sophisticated orchestra that expresses its true potential only
if each member performs the correct task harmonically. Recapitulating its complexity within …

Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen.
Myofibroblasts are major players in the production of collagen, and are differentiated …

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and
under physiological conditions. In the adult heart, activated cardiac fibroblasts also …