Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

The pyridine moiety is an important core structure for a variety of drugs, agrochemicals,
catalysts, and functional materials. Direct functionalization of C− H bonds in pyridines is a …

Skeletal editing is a straightforward synthetic strategy for precise substitution or
rearrangement of atoms in core ring structures of complex molecules; it enables quick …

para-Selective C–H functionalization of pyridines holds a significant value but remains
underdeveloped. Site-switchable C–H functionalization of pyridines under easily tunable …

Asymmetric intermolecular C–H functionalization of pyridines at C3 is unprecedented.
Herein, we report the first examples of such transformations: specifically, C3-allylation of …

Abstract meta-Selective functionalization of electron-rich arenes provides a complementary
route to that of traditional organic synthesis. In classical electrophilic aromatic substitution …

Considering the indispensable significance and utilities of meta-substituted pyridines in
medicinal, chemical as well as materials science, a direct meta-selective C–H …

Herein, we report a one‐pot method for enantioselective C− H allylation of pyridines at C3
via tandem borane and palladium catalysis. This method involves borane‐catalyzed …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …

Pyridine and its reduced form (piperidine) are the most common nitrogen heterocycles in
FDA-approved drugs. Additionally, their presence in alkaloids, ligands for transition metals …