Autophagy mediates an amplification loop during ferroptosis
S Lee, N Hwang, BG Seok, S Lee, SJ Lee… - Cell Death & …, 2023 - nature.com
Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …
The interaction between ferroptosis and inflammatory signaling pathways
Y Chen, ZM Fang, X Yi, X Wei, DS Jiang - Cell death & disease, 2023 - nature.com
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …
Inflammation is one common and effective physiological event that protects against various …
Lipid peroxidation and ferroptosis: The role of GSH and GPx4
F Ursini, M Maiorino - Free Radical Biology and Medicine, 2020 - Elsevier
Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …
[HTML][HTML] Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
T Johansen, T Lamark - Journal of molecular biology, 2020 - Elsevier
Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …
Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …
To address this problem, several therapeutic approaches have been proposed, including …
FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson's disease
Y Tian, J Lu, X Hao, H Li, G Zhang, X Liu, X Li, C Zhao… - …, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons associated with dysregulation of iron homeostasis in the brain …
dopaminergic neurons associated with dysregulation of iron homeostasis in the brain …
[HTML][HTML] Iron homeostasis and oxidative stress: An intimate relationship
Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …
component of various metalloproteins it is involved in critical biochemical processes such as …
The role of NCOA4-mediated ferritinophagy in ferroptosis
N Santana-Codina, A Gikandi, JD Mancias - Ferroptosis: Mechanism and …, 2021 - Springer
Abstract Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates
the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process …
the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process …
[HTML][HTML] NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells
H Zhou, YL Zhou, JA Mao, LF Tang, J Xu, ZX Wang… - Redox biology, 2022 - Elsevier
Ferroptosis is a newly recognized form of regulated cell death that is characterized by
severe lipid peroxidation initiated by iron overload and the generation of reactive oxygen …
severe lipid peroxidation initiated by iron overload and the generation of reactive oxygen …