Due to deadly toxicity and high environmental stability of the nerve agent VX, an efficient
decontamination approach is desperately needed in tackling its severe threat to human …

The highly homologous hydroxynitrile lyases from Manihot esculent (Me HNL) and Hevea
brasiliensis (Hb HNL) both belong to the α/β-hydrolase superfamily, and they convert …

Base excision of mismatched or damaged nucleotides catalyzed by glycosylase enzymes is
the first step of the base excision repair system, a machinery preserving the integrity of DNA …

Despite the inherent stability of glycosidic linkages in nucleic acids that connect the
nucleobases to sugar–phosphate backbones, cleavage of these bonds is often essential for …

Chymotrypsin inhibitor 2 (CI2) is a special serine protease inhibitor which can resist
hydrolysis for several days with a rapid equilibrium between the Michaelis complex and acyl …

The pyrimidine-specific nucleoside hydrolase Yeik (CU-NH) from Escherichia coli cleaves
the N-glycosidic bond of uridine and cytidine with a 102–104-fold faster rate than that of …

Herbicides are crucial tools used to control unwanted vegetation to increase crop yields and
landscape aesthetics. Current herbicides target metabolic pathways for protein production in …

Enzymatic catalytic processes generally involve substrate delivery, selective catalytic
reaction, and product release. Owing to the complex protein environment effect, any …

酶催化包括底物到活性区的输运, 选择催化化学反应及产物释放等复杂过程,
由于复杂的蛋白质环境效应, 任一化学和非化学过程都有可能是决定酶活性的关键步骤 …

The remarkable capability of an enzyme isn't only determined by its active site but also
controlled by the environment. To unravel the environment role in catalysis, the dynamic …