Covering: up to 2022 Pyrroloindoline is a privileged tricyclic indoline motif widely present in
many biologically active and medicinally valuable natural products. Thus, understanding the …

Covering: up to August 2020 The dramatic increase in the identification of dimeric natural
products generated by microorganisms and plants has played a significant role in drug …

Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

The cytochrome P450 (CYP) AspB is involved in the biosynthesis of the diketopiperazine
(DKP) aspergilazine A. Tryptophan-linked dimeric DKP alkaloids are a large family of natural …

In the biosynthesis of the tryptophan‐linked dimeric diketopiperazines (DKPs), cytochromes
P450 selectively couple DKP monomers to generate a variety of intricate and isomeric …

Heterodimeric tryptophan‐containing diketopiperazines (HTDKPs) are an important class of
bioactive secondary metabolites. Biosynthesis offers a practical opportunity to access their …

Diketopiperazines are the smallest cyclic peptides comprising two amino acids connected
via two peptide bonds. They can be biosynthesized in nature by two different enzyme …

P450 NascB catalyzes the coupling of cyclo-(l-tryptophan-l-proline)(1) to generate (−)-
naseseazine C (2) through intramolecular C–N bond formation and intermolecular C–C …

Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

We conducted global genome mining of 162,672 bacterial genomes and identified 829
cyclodipeptide (CDP) biosynthesis gene clusters (BGC) containing a cytochrome P450 …