SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction
E Ballana, JA Esté - Trends in microbiology, 2015 - cell.com
SAMHD1 is a triphosphohydrolase enzyme that controls the intracellular level of
deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune sensing and …
deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune sensing and …
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity
Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …
deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the …
SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination
W Daddacha, AE Koyen, AJ Bastien, PSE Head… - Cell reports, 2017 - cell.com
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) has a dNTPase-
independent function in promoting DNA end resection to facilitate DNA double-strand break …
independent function in promoting DNA end resection to facilitate DNA double-strand break …
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and
the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates …
the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates …
Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect
A Bhattacharya, Z Wang, T White, C Buffone… - Scientific reports, 2016 - nature.com
SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of
retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the …
retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the …
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle
AFR Sommer, L Rivière, B Qu, K Schott, M Riess… - Scientific reports, 2016 - nature.com
Deoxynucleotide triphosphates (dNTPs) are essential for efficient hepatitis B virus (HBV)
replication. Here, we investigated the influence of the restriction factor SAMHD1, a dNTP …
replication. Here, we investigated the influence of the restriction factor SAMHD1, a dNTP …
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
Background SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of
HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been …
HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been …
Substrates and Inhibitors of SAMHD1
JA Hollenbaugh, J Shelton, S Tao, S Amiralaei, P Liu… - PloS one, 2017 - journals.plos.org
SAMHD1 hydrolyzes 2'-deoxynucleoside-5'-triphosphates (dNTPs) into 2'-deoxynucleosides
and inorganic triphosphate products. In this paper, we evaluated the impact of 2'sugar …
and inorganic triphosphate products. In this paper, we evaluated the impact of 2'sugar …
Single-stranded nucleic acids bind to the tetramer interface of SAMHD1 and prevent formation of the catalytic homotetramer
KJ Seamon, NN Bumpus, JT Stivers - Biochemistry, 2016 - ACS Publications
Sterile alpha motif and HD domain protein 1 (SAMHD1) is a unique enzyme that plays
important roles in nucleic acid metabolism, viral restriction, and the pathogenesis of …
important roles in nucleic acid metabolism, viral restriction, and the pathogenesis of …