血管内皮细胞和内皮细胞释放的活性因子是调控血管舒张功能的重要因素. 糖尿病是慢性心血管
疾病的高危因素之一. 目前认为高糖和糖尿病引起的内皮细胞功能障碍是造成血管功能改变 …

While Rho-signalling controlling vascular contraction is a canonical mechanism, with the
modern approaches used in research, we are advancing our understanding and details into …

The adipose tissue extracellular matrix (ECM) regulates adipocyte cellular metabolism and
is altered in obesity and type 2 diabetes, but mechanisms underlying ECM-adipocyte …

This review examines the impact of obesity on the pathophysiology of heart failure with
preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF …

Metabolic syndrome (MetS) is a global health challenge characterized as a group of risk
factors for developing atherosclerotic cardiovascular disease. Although visceral adipose …

Antithrombotic drugs are widely used for primary and secondary prevention, as well as
treatment of many cardiovascular disorders. Over the past few decades, major advances in …

The cardiovascular and renovascular complications of metabolic deterioration are
associated with localized adipose tissue dysfunction. We have previously demonstrated that …

In previous years, it has been found that Rhodiola has a wide range of pharmacological
effects in diseases of the cardiovascular system, as it can remove superoxide anions and …

Chronic wounds with high disability are among the most common and serious complications
of diabetes. Angiogenesis dysfunction impair wound healing in patients with diabetes …

Abstract The small GTPase RhoA and the downstream Rho kinase (ROCK) regulate several
cell functions and pathological processes in the vascular system that contribute to the age …