Unlocking the Friedel-Crafts arylation of primary aliphatic alcohols and epoxides driven by hexafluoroisopropanol

S Zhang, M Vayer, F Noel, VD Vuković, A Golushko… - Chem, 2021 - cell.com
Alcohols and epoxides are arguably ideal electrophiles for the Friedel-Crafts alkylation,
since they are widely available, require no pre-activation, and produce no stoichiometric …

Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)–H Arylation

M Maetani, J Zoller, B Melillo, O Verho… - Journal of the …, 2017 - ACS Publications
The development of new antimalarial therapeutics is necessary to address the increasing
resistance to current drugs. Bicyclic azetidines targeting Plasmodium falciparum …

Thiazole analogues of the marine alkaloid nortopsentin as inhibitors of bacterial biofilm formation

A Carbone, S Cascioferro, B Parrino, D Carbone… - Molecules, 2020 - mdpi.com
Anti-virulence strategy is currently considered a promising approach to overcome the global
threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm …

Intramolecular Fischer indole synthesis for the direct synthesis of 3, 4-fused tricyclic indole and application to the total synthesis of (−)-aurantioclavine

J Park, DH Kim, T Das, CG Cho - Organic letters, 2016 - ACS Publications
Aryl hydrazides with a ketone or aldehyde containing side chains linked to the meta-position
of the aromatic ring undergo acid-promoted intramolecular Fischer indole synthesis to …

Nickel-catalyzed asymmetric hydrogenation of cyclic sulfamidate imines: Efficient synthesis of chiral cyclic sulfamidates

Y Liu, Z Yi, X Tan, XQ Dong, X Zhang - Iscience, 2019 - cell.com
Chiral cyclic sulfamidates are useful building blocks to construct compounds, such as chiral
amines, with important applications. Often these compounds can only be generated through …

Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade

L Martínez-Montero, D Tischler, P Süss… - Catalysis Science & …, 2021 - pubs.rsc.org
Enantioenriched azido alcohols are precursors for valuable chiral aziridines and 1, 2-amino
alcohols, however their chiral substituted analogues are difficult to access. We established a …

One Pot Asymmetric Synthesis of (R)‐Phenylglycinol from Racemic Styrene Oxide via Cascade Biocatalysis

ZB Sun, ZJ Zhang, FL Li, Y Nie, HL Yu, JH Xu - ChemCatChem, 2019 - Wiley Online Library
Abstract (R)‐Phenylglycinol is an important chiral building block for pharmaceutical and fine
chemical industry, and its efficient synthesis from cheap and commercially available starting …

Regiodivergent and stereoselective hydroxyazidation of alkenes by biocatalytic cascades

JF Wu, NW Wan, YN Li, QP Wang, BD Cui, WY Han… - Iscience, 2021 - cell.com
Asymmetric functionalization of alkenes allows the direct synthesis of a wide range of chiral
compounds. Vicinal hydroxyazidation of alkenes provides a desirable path to 1, 2 …

Enantioselective synthesis of γ-Phenyl-γ-amino vinyl phosphonates and sulfones and their application to the synthesis of novel highly potent antimalarials

EK Aratikatla, M Kalamuddin, P Malhotra… - ACS …, 2020 - ACS Publications
Racemic and enantioselective syntheses of γ-phenyl-γ-amino vinyl phosphonates and
sulfones have been achieved using Horner–Wadsworth–Emmons olefination of trityl …

[Fe3O4@SiO2@(CH2)3im]C6F5O as a New Hydrophilic and Task‐Specific Nanomagnetic Catalyst: Application for Synthesis of β‐Azido Alcohols and …

J Afsar, MA Zolfigol, A Khazaei - ChemistrySelect, 2018 - Wiley Online Library
Abstract [Fe3O4@ SiO2@(CH2) 3im] C6F5O was designed, synthesized and characterized
by various techniques such as Fourier transform spectroscopy infrared (FT‐IR), X‐ray …