The brain functions through coordinated activity among distributed regions. Wide-field
calcium imaging, combined with improved genetically encoded calcium indicators, allows …

Simple Summary We review advances in the properties of calcium sensors, microscopy, and
data analysis that have brought about the ability to image large contiguous regions of the …

A long-standing question in systems neuroscience is to what extent task-relevant features of
neocortical processing are localized or distributed. Coordinated activity across the neocortex …

In rodent motor cortex, the rostral forelimb area (RFA) and the caudal forelimb area (CFA)
are major actors in orchestrating the control of complex forelimb movements. However, their …

Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in
basic neuroscience and in all the biomedical field. Optogenetics is well-suited to this …

Genetically encoded calcium indicators (GECIs) are useful reporters of cell-signaling,
neuronal, and network activities. We have generated novel fast variants and investigated the …

We employ transcranial wide-field single-photon imaging to compare genetically encoded
calcium sensors under transgenic or viral vector expression strategies. Awake, head-fixed …

Large-scale cortical dynamics play a crucial role in many cognitive functions such as goal-
directed behaviors, motor learning and sensory processing. It is well established that brain …

In most species, survival relies on the hypothalamic control of endocrine axes that regulate
critical functions such as reproduction, growth, and metabolism. For decades, the complexity …

Stroke is a debilitating condition affecting millions of people worldwide. The development of
improved rehabilitation therapies rests on finding biomarkers suitable for tracking functional …