Prolactin, a hormone that has been studied for almost a century, has evolved from a
reproductive regulator to a key player in metabolic health. Initially identified for its lactogenic …

Background Prolactin (PRL) is a pituitary hormone promoting lactation in response to the
suckling reflex. Beyond its well‐known effects, novel tissue‐specific and metabolic functions …

Aims/hypothesis Inflammation induces beta cell dysfunction and demise but underlying
molecular mechanisms remain unclear. The apolipoprotein L (APOL) family of genes has …

Type 1 diabetes is associated with the destruction of pancreatic beta cells, which is
mediated via an autoimmune mechanism and consequent inflammatory processes. In this …

Exposure to environmental BaP or its metabolite BPDE causes trophoblast cell dysfunctions
to induce miscarriage (abnormal early embryo loss), which might be generally regulated by …

Extracellular vesicles (EVs) mediate the intercellular crosstalk by transferring functional
cargoes. Recently, we have discovered that BaP/BPDE exposure suppresses trophoblast …

The homeo-fit-prolactin hypothesis proposes a causal metabolic role for prolactin with
hypoprolactinemia and hyperprolactinemia leading to adverse metabolic alterations …

Objectives Patients with type 1 diabetes mellitus have been reported to have elevated
prolactin levels and a possible relationship between prolactin levels and the development of …

Elevated free fatty acids (FFAs) impair beta cell function and reduce beta cell mass as a
consequence of the lipotoxicity that occurs in type 2 diabetes (T2D). We previously reported …

FAS-associated protein with death domain (FADD) is the pivotal adaptor protein, which
transmits apoptotic signals mediated by the death receptors. Here we report that high FADD …