Survivin: a unique target for tumor therapy

H Garg, P Suri, JC Gupta, GP Talwar, S Dubey - Cancer cell international, 2016 - Springer
Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved
in inhibition of apoptosis and regulation of cell cycle. These functional attributes make …

The survivin molecule as a double‐edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer

A Rafatmanesh, M Behjati, N Mobasseri… - Journal of Cellular …, 2020 - Wiley Online Library
Survivin is a member of the family of apoptosis inhibitory proteins with increased expression
level in most cancerous tissues. Evidence shows that survivin plays regulatory roles in …

BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas

I Mumlek, P Ozretić, M Sabol, M Leović… - International journal of …, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma
(OPSCC) are the most common types of cancers in the head and neck region (HNSCC) …

Clinico-pathologic relevance of Survivin splice variant expression in cancer

R de Necochea-Campion, CS Chen, S Mirshahidi… - Cancer letters, 2013 - Elsevier
Survivin is a member of the inhibitor of apoptosis (IAP) family and has multifunctional
properties that include aspects of proliferation, invasion and cell survival control. Survivin is …

Survivin in breast cancer: a review

MA Martínez-Sifuentes… - Genetic Testing and …, 2022 - liebertpub.com
Breast cancer is the most frequently diagnosed cancer in women and ranks second among
causes for cancer-related death in women. Gene technology has led to the recognition that …

Survivin expression impacts prognostically on NSCLC but not SCLC

A Rosato, C Menin, D Boldrin, S Dalla Santa, L Bonaldi… - Lung Cancer, 2013 - Elsevier
Survivin is expressed in lung cancer and in most cancer tissues and has a significant impact
on prognosis. This work aimed to comparatively assess survivin expression and significance …

microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients

H Ebrahimiyan, N Rezaei, M Vojdanian… - International Journal …, 2019 - Wiley Online Library
Aim Impaired regulation of immune tolerance results in autoimmune diseases, such as
rheumatoid arthritis (RA). Survivin is an anti‐apoptotic protein and can induce cellular …

Polymorphisms in Survivin (BIRC5 Gene) Are Associated with Age of Onset in Breast Cancer Patients

I Sušac, P Ozretić, M Gregorić… - Journal of …, 2019 - Wiley Online Library
Survivin, encoded by BIRC5 gene (baculoviral IAP repeat containing 5), belongs to the
family of inhibitors of apoptosis proteins (IAPs). In mammalian cells it participates in the …

High expression of survivin and its splice variants survivin ΔEx3 and survivin 2 B in oral cancers

R Mishra, V Palve, S Kannan, S Pawar… - Oral surgery, oral medicine …, 2015 - Elsevier
Objectives We have previously reported inactivation of p53 in 46% of Indian patients with
oral cancer. Survivin, a p53 target gene and an inhibitor of apoptosis protein (IAP), is …

Survivin gene promoter polymorphism‐31G/C as a risk factor for keratocystic odontogenic tumor development

M Andric, N Nikolic, M Boskovic… - European journal of …, 2012 - Wiley Online Library
Andric M, Nikolic N, Boskovic M, Milicic B, Skodric S, Basta Jovanovic G, Milasin J. Survivin
gene promoter polymorphism‐31G/C as a risk factor for keratocystic odontogenic tumor …