Cryopyrin-associated periodic syndrome (CAPS) is a rare, heterogeneous disease entity
associated with NLRP3 gene mutations and increased interleukin-1 (IL-1) secretion. Early …

Autoimmune diseases affect up to 10% of the world's population and, as a whole, they are
far more common in females, although differences exist according to the single disease and …

BD is a systemic inflammatory disease with a variable vasculitis. Paediatric onset is very rare
and carries a strong genetic component. Oral ulcers and fever of unknown origin are …

Objectives The association between mutations in TNFAIP3, encoding the NF-kB regulatory
protein A20, and a new autoinflammatory disease has recently been recognised. This study …

Abstract Background We hypothesized that Behçet's disease (BD) consists of several clinical
subtypes with different severity, resulting in heterogeneity of the disease. Here, we …

Behçet's disease (BD) is a systemic variable vessel vasculitis that involves the skin, mucosa,
joints, eyes, arteries, veins, nervous system and gastrointestinal system, presenting with …

Behçet's Disease (BD) is a systemic vasculitis firstly described as a disorder causing
aphthous lesion in oral and genital mucosae and uveitis. The disease has an extremely …

Behçet's disease (BD) and Crohn's disease (CD) are chronic immune-mediated,
inflammatory disorders affecting many different systems (joints, skin, eyes, gastrointestinal …

The term vasculitis covers heterogeneous disorders that share the presence of inflammation
of blood vessel walls. Immune cell infiltrates can vary significantly and involve granulocytes …

Objectives To describe the clinical characteristics, treatment response and genetic findings
in a large cohort of patients with undefined systemic autoinflammatory diseases (SAIDs) …