Various diseases remain untreated due to lack of suitable therapeutic moiety or a suitable
drug delivery device, especially where toxicities and side effects are the primary reason for …

Cancer stem cells (CSC) are a distinct subpopulation within a tumor. They are able to self-
renew and differentiate and possess a high capability to repair DNA damage, exhibit low …

Immune checkpoint inhibitors have been successful across several tumor types; however,
their efficacy has been uncommon and unpredictable in glioblastomas (GBM), where< 10 …

High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …

An outstanding characteristic of gliomas is their infiltration into brain parenchyma, a property
that impairs complete surgical resection; consequently, these tumors might recur, resulting in …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain tumor, and the
clinically available approaches for its treatment are not curative. Despite the intensive …

Rapid growth and perivascular invasion are hallmarks of glioblastoma (GBM) that have
been attributed to the presence of cancer stem-like cells (CSCs) and their association with …

Glioblastoma (GBM) is the most common and devastating primary brain tumor, leading to a
uniform fatality after diagnosis. A major difficulty in eradicating GBM is the presence of …

Background Glioblastoma is the most common primary malignant intracranial tumor with
poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding …

Advances in cancer biology are revealing the importance of the cancer cell
microenvironment on tumorigenesis and cancer progression. Hyaluronan (HA), the main …