In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications
MJ Ramos, L Bandiera, F Menolascina, JA Fallowfield - Iscience, 2022 - cell.com
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction
S Cai, M Zhao, B Zhou, A Yoshii… - The Journal of …, 2023 - Am Soc Clin Investig
Innate immune cells play important roles in tissue injury and repair following acute
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in …
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in …
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
H Yin, X Zhang, P Yang, X Zhang, Y Peng, D Li… - Nature …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown
to play important roles in various biological processes. However, the roles of m6A …
to play important roles in various biological processes. However, the roles of m6A …
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death
Ferroptotic death is the penalty for losing control over three processes—iron metabolism,
lipid peroxidation and thiol regulation—that are common in the pro-inflammatory …
lipid peroxidation and thiol regulation—that are common in the pro-inflammatory …
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2
T Feng, X Zhao, P Gu, W Yang, C Wang, Q Guo… - Nature …, 2022 - nature.com
Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and
pathology of metabolic complications. Here we report that in adipocytes, elevated lactate …
pathology of metabolic complications. Here we report that in adipocytes, elevated lactate …
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis
Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close
proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead …
proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead …
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
VG Magupalli, R Negro, Y Tian, AV Hauenstein… - Science, 2020 - science.org
INTRODUCTION Canonical inflammasomes are multicomponent protein complexes that
play key roles in immune surveillance of infections and danger by activating caspase-1 …
play key roles in immune surveillance of infections and danger by activating caspase-1 …
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with
pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a …
pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of a …
M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors
Cancer immunotherapy modulates immune cells to induce antitumor immune responses.
Tumors employ immune checkpoints to evade immune cell attacks. Immune checkpoint …
Tumors employ immune checkpoints to evade immune cell attacks. Immune checkpoint …