Obesity II: establishing causal links between chemical exposures and obesity
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …
prevailing view is that obesity results from an imbalance between energy intake and …
Obesity III: Obesogen assays: Limitations, strengths, and new directions
CD Kassotis, FS Vom Saal, PJ Babin… - Biochemical …, 2022 - Elsevier
There is increasing evidence of a role for environmental contaminants in disrupting
metabolic health in both humans and animals. Despite a growing need for well-understood …
metabolic health in both humans and animals. Despite a growing need for well-understood …
Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
A Braeuning, P Balaguer, W Bourguet… - Frontiers in …, 2023 - frontiersin.org
In past times, the analysis of endocrine disrupting properties of chemicals has mainly been
focused on (anti-) estrogenic or (anti-) androgenic properties, as well as on aspects of …
focused on (anti-) estrogenic or (anti-) androgenic properties, as well as on aspects of …
Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures
Chronic health conditions are rapidly increasing in prevalence and cost to society
worldwide: in the US,> 42% of adults aged 20 and older are currently classified as obese …
worldwide: in the US,> 42% of adults aged 20 and older are currently classified as obese …
Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish
S Thrikawala, F Mesmar, B Bhattacharya… - Toxicological …, 2023 - academic.oup.com
Triazoles are a major group of azole fungicides commonly used in agriculture, and
veterinary and human medicine. Maternal exposure to certain triazole antifungal medication …
veterinary and human medicine. Maternal exposure to certain triazole antifungal medication …
Nasopharyngeal Carcinoma Cell Lines: Reliable Alternatives to Primary Nasopharyngeal Cells?
A Makowska, R Weiskirchen - Cells, 2024 - mdpi.com
Nasopharyngeal carcinoma (NPC) is a type of cancer that originates from the mucosal lining
of the nasopharynx and can invade and spread. Although contemporary chemoradiotherapy …
of the nasopharynx and can invade and spread. Although contemporary chemoradiotherapy …
The Mixture of Bisphenol-A and Its Substitutes Bisphenol-S and Bisphenol-F Exerts Obesogenic Activity on Human Adipose-Derived Stem Cells
Bisphenol A (BPA) and its substitutes, bisphenol F (BPF) and S (BPS), have previously
shown in vitro obesogenic activity. This study was designed to investigate their combined …
shown in vitro obesogenic activity. This study was designed to investigate their combined …
Nonylphenol polyethoxylates enhance adipose deposition in developmentally exposed zebrafish
CD Kassotis, MK LeFauve, YTT Chiang, MM Knuth… - Toxics, 2022 - mdpi.com
Alkylphenol polyethoxylates (APEOs), such as nonylphenol ethoxylates (NPEOs), are high-
production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide …
production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide …
[HTML][HTML] High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells (hMSCs)
K Norgren, A Tuck, AV Silva, P Burkhardt… - Food and Chemical …, 2022 - Elsevier
In vitro models of adipogenesis are phenotypic assays that most closely mimic the increase
of adipose tissue in obesity. Current models, however, often lack throughput and sensitivity …
of adipose tissue in obesity. Current models, however, often lack throughput and sensitivity …
Molecular Assessment of Proadipogenic Effects for Common-Use Contraceptives and Their Mixtures
YTT Chiang, CD Kassotis - Endocrinology, 2024 - academic.oup.com
Hormonal contraceptives are widely prescribed due to their effectiveness and convenience
and have become an integral part of family planning strategies worldwide. In the United …
and have become an integral part of family planning strategies worldwide. In the United …