Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Obesity III: Obesogen assays: Limitations, strengths, and new directions

CD Kassotis, FS Vom Saal, PJ Babin… - Biochemical …, 2022 - Elsevier
There is increasing evidence of a role for environmental contaminants in disrupting
metabolic health in both humans and animals. Despite a growing need for well-understood …

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

A Braeuning, P Balaguer, W Bourguet… - Frontiers in …, 2023 - frontiersin.org
In past times, the analysis of endocrine disrupting properties of chemicals has mainly been
focused on (anti-) estrogenic or (anti-) androgenic properties, as well as on aspects of …

Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures

R Bérubé, MK LeFauve, S Heldman… - Science of the Total …, 2023 - Elsevier
Chronic health conditions are rapidly increasing in prevalence and cost to society
worldwide: in the US,> 42% of adults aged 20 and older are currently classified as obese …

Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish

S Thrikawala, F Mesmar, B Bhattacharya… - Toxicological …, 2023 - academic.oup.com
Triazoles are a major group of azole fungicides commonly used in agriculture, and
veterinary and human medicine. Maternal exposure to certain triazole antifungal medication …

Nasopharyngeal Carcinoma Cell Lines: Reliable Alternatives to Primary Nasopharyngeal Cells?

A Makowska, R Weiskirchen - Cells, 2024 - mdpi.com
Nasopharyngeal carcinoma (NPC) is a type of cancer that originates from the mucosal lining
of the nasopharynx and can invade and spread. Although contemporary chemoradiotherapy …

The Mixture of Bisphenol-A and Its Substitutes Bisphenol-S and Bisphenol-F Exerts Obesogenic Activity on Human Adipose-Derived Stem Cells

I Reina-Pérez, A Olivas-Martínez, V Mustieles… - Toxics, 2022 - mdpi.com
Bisphenol A (BPA) and its substitutes, bisphenol F (BPF) and S (BPS), have previously
shown in vitro obesogenic activity. This study was designed to investigate their combined …

Nonylphenol polyethoxylates enhance adipose deposition in developmentally exposed zebrafish

CD Kassotis, MK LeFauve, YTT Chiang, MM Knuth… - Toxics, 2022 - mdpi.com
Alkylphenol polyethoxylates (APEOs), such as nonylphenol ethoxylates (NPEOs), are high-
production-volume surfactants used in laundry detergents, hard-surface cleaners, pesticide …

[HTML][HTML] High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells (hMSCs)

K Norgren, A Tuck, AV Silva, P Burkhardt… - Food and Chemical …, 2022 - Elsevier
In vitro models of adipogenesis are phenotypic assays that most closely mimic the increase
of adipose tissue in obesity. Current models, however, often lack throughput and sensitivity …

Molecular Assessment of Proadipogenic Effects for Common-Use Contraceptives and Their Mixtures

YTT Chiang, CD Kassotis - Endocrinology, 2024 - academic.oup.com
Hormonal contraceptives are widely prescribed due to their effectiveness and convenience
and have become an integral part of family planning strategies worldwide. In the United …