From actin waves to mechanism and back: how theory aids biological understanding

C Beta, L Edelstein-Keshet, N Gov, A Yochelis - Elife, 2023 - elifesciences.org
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

The excitable nature of polymerizing actin and the Belousov-Zhabotinsky reaction

M Riedl, M Sixt - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
The intricate regulatory processes behind actin polymerization play a crucial role in cellular
biology, including essential mechanisms such as cell migration or cell division. However, the …

Nanotopography modulates intracellular excitable systems through cytoskeleton actuation

Q Yang, Y Miao, P Banerjee… - Proceedings of the …, 2023 - National Acad Sciences
Cellular sensing of most environmental cues involves receptors that affect a signal-
transduction excitable network (STEN), which is coupled to a cytoskeletal excitable network …

Excitable systems: A new perspective on the cellular impact of elongate mineral particles

S Gu, A Bull, JK Perry, A Huang, MJ Hourwitz… - Environmental …, 2023 - Elsevier
We investigate how the geometry of elongate mineral particles (EMPs) in contact with cells
influences esotaxis, a recently discovered mechanism of texture sensing. Esotaxis is based …

Decoding natural astrocyte rhythms: dynamic actin waves result from environmental sensing by primary rodent astrocytes

KM O'Neill, E Saracino, B Barile, NJ Mennona… - Advanced …, 2023 - Wiley Online Library
Astrocytes are key regulators of brain homeostasis, equilibrating ion, water, and
neurotransmitter concentrations and maintaining essential conditions for proper cognitive …

Machine learning from limited data: Predicting biological dynamics under a time-varying external input

H Kang, K Srinivasan, W Losert - arXiv preprint arXiv:2408.07998, 2024 - arxiv.org
Reservoir computing (RC) is known as a powerful machine learning approach for learning
complex dynamics from limited data. Here, we use RC to predict highly stochastic dynamics …

Electrotaxis disrupts patterns of cell-cell interactions of human corneal epithelial cells in vitro

RM Crossley, SF Martina-Perez - bioRxiv, 2024 - biorxiv.org
Electrotaxis, the process by which eukaryotic cells establish a polarity and move
directionally along an electric field, is a well-studied mechanism to steer the migration of …

Coupled Biomechanical and Ionic Excitability in Developing Neural Cell Networks

SJ Gates III, P Alvarez, K Cao, K O'Neill, W Losert - bioRxiv, 2023 - biorxiv.org
Waves and oscillations play a key role in the flow and processing of information in the brain.
Recent work has demonstrated that in addition to electrical activity, biomechanical signaling …

Data driven approach towards quantifying dynamics in biological systems

S Saha - 2023 - search.proquest.com
In this thesis, we develop data driven formalism for analysing features that govern dynamics
in biological systems. We first consider the social amoeba Dictyostelium discoideum as a …

Collective Dynamics of Astrocyte and Cytoskeletal Systems

NJ Mennona - 2024 - search.proquest.com
Advances in imaging and biological sample preparations now allow researchers to study
collective behavior in cellular networks with unprecedented detail. Imaging the electrical …