Although uncommon, breast cancer in young women is worthy of special attention due to the
unique and complex issues that are raised. This article reviews specific challenges …

About one in 300 women will be diagnosed with breast cancer before the age of 40.
Advances in screening have not had an impact on mortality in women who are too young to …

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …

Background Li–Fraumeni syndrome (LFS) is a rare autosomal dominant cancer
predisposition syndrome. Most families fulfilling the classical diagnostic criteria harbour …

All cancers develop as a result of mutations in certain genes, such as those involved in the
regulation of cell growth and/or DNA repair, 1, 2 but not all of these mutations are inherited …

Background Breast cancer at a young age is associated with poor prognosis. The
Prospective Study of Outcomes in Sporadic and Hereditary Breast Cancer (POSH) was …

Li–Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant
inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer …

Approximately 10% of breast cancers are associated with the inheritance of a pathogenic
variant (PV) in one of the breast cancer susceptibility genes. Multiple breast cancer …

Introduction The Li–Fraumeni Syndrome is caused by a germline TP53 mutation and is
associated with a high risk of breast cancer at young ages. Basal (triple negative) breast …

Germline mutations in BRCA1, BRCA2 and TP53 genes have been identified as one of the
most important disease-causing issues in young breast cancer patients worldwide. The …