Myeloid neoplasms, including acute myeloid leukemia (AML), myeloproliferative neoplasms
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …

Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …

Baicalein is a natural flavonoid extracted from the root of Scutellaria baicalensis that exhibits
a variety of pharmacological activities. In this study, we investigated the molecular …

Compounds targeting the circadian clock have been identified as potential treatments for
clock-related diseases, including cancer. Our cell-based phenotypic screen revealed …

The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

Protein kinase CK2 (CK2) is a ubiquitous holoenzyme involved in a wide array of
developmental processes. The involvement of CK2 in events such as neurogenesis …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

The bone marrow microenvironment promotes proliferation and drug resistance in chronic
lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear …

Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population
of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …