This report calls on the nation—its leaders, its mental health research and service provision
agencies, its schools, its primary care medical systems, its community-based organizations …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Although we have studied schizophrenia as a major disease entity over the past century, its
causes and pathogenesis remain obscure. In this article, we critically review genetic and …

Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and
Possibilities | The National Academies Press Skip to main content Navigate to Help Ordering …

In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

The research of the glutamatergic system in schizophrenia has advanced with the use of
non-competitive antagonists of glutamate NMDA receptors (phencyclidine, ketamine, and …

Neuregulin 1 (NRG1) is a trophic factor thought to play a role in neural development. Recent
studies suggest that it may regulate neurotransmission, mechanisms of which remain …

Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …

Maternal infection during pregnancy increases the risk of schizophrenia and other brain
disorders of neurodevelopmental origin in the offspring. A multitude of infectious agents …

Sex differences in the genetic epidemiology and clinical features of psychiatric disorders are
well recognized, but the individual genes contributing to these effects have rarely been …