The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

A great effort of research has been devoted in the last few years to developing new anti-HBV
therapies of finite duration that also provide effective sustained control of virus replication …

Hepatocellular carcinoma (HCC) is highly malignant and prone to metastasize due to the
heterogeneous and immunosuppressive tumor microenvironment (TME). Programmed cell …

The mechanisms of liver hepatitis B virus (HBV)–induced systemic immune tolerance are
still elusive, and the role of γδT cells has not yet been described. We examined the function …

Excitement is growing for therapies that harness the power of patients' immune systems to
combat their diseases. One approach to immunotherapy involves engineering patients' own …

The T cell receptor Vγ9Vδ2 T cells bridge innate and adaptive antimicrobial immunity in
primates. These Vγ9Vδ2 T cells respond to phosphoantigens (pAgs) present in microbial or …

The complexity of the human immune system is exacerbated by age-related changes to
immune cell functionality. Many of these age-related effects remain undescribed or driven by …

Conventional adaptive T cell responses contribute to liver inflammation and fibrogenesis,
especially in chronic viral infections and autoimmune hepatitis. However, the role of …

Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through
directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to …

The innate system constitutes a first-line defence mechanism against pathogens. 80% of the
blood supply entering the human liver arrives from the splanchnic circulation through the …