Lactation is critical to infant short-term and long-term health and protects mothers from
breast cancer, ovarian cancer and type 2 diabetes mellitus. The mammary gland is a …

Abstract Prolactin (PRL) is a 23-kDa protein hormone that binds to a single-span membrane
receptor, a member of the cytokine receptor superfamily, and exerts its action via several …

Long noncoding RNAs (lncRNAs) are increasingly recognized to play major regulatory roles
in development and disease. To identify novel regulators in breast biology, we identified …

The transition from pregnancy to lactation is a critical event in the survival of the newborn
since all the nutrient requirements of the infant are provided by milk. While milk contains …

The mammary gland of the lactating mouse synthesizes and secretes milk lipid equivalent to
its entire body weight in a single 20-day lactation cycle, making it one of the most active lipid …

Glucose is the major precursor of lactose, which is synthesized in Golgi vesicles of
mammary secretory alveolar epithelial cells during lactation. Glucose is taken up by …

Prolactin has a rich mechanistic set of actions and signaling in order to elicit developmental
effects in mammals. Historically, prolactin has been appreciated as an endocrine peptide …

BACKGROUND: Genes underlying circadian rhythm generation are expressed in many
tissues. We explore a role for circadian rhythms in the timing and efficacy of mouse …

Mammary morphogenesis is orchestrated with other reproductive events by pituitary-driven
changes to the systemic hormone environment, initiating the formation of a mammary ductal …

The molecular physiology underlying human milk production is largely unknown because of
limitations in obtaining tissue samples. Determining gene expression in normal lactating …