Neuronal nicotinic acetylcholine receptors comprise a heterogeneous class of cationic
channels that is present throughout the nervous system. These channels are involved both …

Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …

Neuronal cholinergic nicotinic receptors (nAChRs) are a heterogeneous class of cationic
channels that are widely distributed in the nervous system that have specific functional and …

α9α10 nicotinic acetylcholine receptors (nAChRs) have been identified in a variety of tissues
including lymphocytes and dorsal root ganglia; except in the case of the auditory system, the …

Cysteine-rich peptides from the venom of cone snails (Conus) target a wide variety of
different ion channels. One family of conopeptides, the α-conotoxins, specifically target …

In the four decades since toxinologists in Australia and elsewhere started to investigate the
active constituents of venomous cone snails, a wealth of information has emerged on the …

We identified a previously unidentified conotoxin gene from Conus generalis whose
precursor signal sequence has high similarity to the O1-gene conotoxin superfamily. The …

The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion
channels. It is vital for neuromuscular transmission and an important regulator of …

The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to
mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the …