The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

Primary aldosteronism is a common cause of secondary hypertension associated with
excess cardiovascular morbidities. Primary aldosteronism is underdiagnosed because it …

Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality
rates than essential hypertension. The Japan Endocrine Society (JES) has developed an …

Autonomous aldosterone overproduction represents the underlying condition of 5–10% of
patients with arterial hypertension and carries a significant burden of mortality and morbidity …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

Objective: To develop clinical practice guidelines for the management of patients with
primary aldosteronism. Participants: The Task Force included a chair, selected by the …

The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

The molecular underpinnings that drive the heterogeneity of KRAS-mutant lung
adenocarcinoma are poorly characterized. We performed an integrative analysis of …