Allergen-induced airway responses
GM Gauvreau, AI El-Gammal… - European Respiratory …, 2015 - Eur Respiratory Soc
Environmental allergens are an important cause of asthma and can contribute to loss of
asthma control and exacerbations. Allergen inhalation challenge has been a useful clinical …
asthma control and exacerbations. Allergen inhalation challenge has been a useful clinical …
[HTML][HTML] Airway hyperresponsiveness; smooth muscle as the principal actor
Airway hyperresponsiveness (AHR) is a defining characteristic of asthma that refers to the
capacity of the airways to undergo exaggerated narrowing in response to stimuli that do not …
capacity of the airways to undergo exaggerated narrowing in response to stimuli that do not …
Effect of bronchoconstriction on airway remodeling in asthma
CL Grainge, LCK Lau, JA Ward, V Dulay… - … England Journal of …, 2011 - Mass Medical Soc
Background Asthma is characterized pathologically by structural changes in the airway,
termed airway remodeling. These changes are associated with worse long-term clinical …
termed airway remodeling. These changes are associated with worse long-term clinical …
Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite
ZG Chen, TT Zhang, HT Li, FH Chen, XL Zou, JZ Ji… - PloS one, 2013 - journals.plos.org
Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to
airway remodeling and the deterioration of lung function. However, the initiating factor that …
airway remodeling and the deterioration of lung function. However, the initiating factor that …
An official American Thoracic Society research statement: current challenges facing research and therapeutic advances in airway remodeling
YS Prakash, AJ Halayko, R Gosens… - American Journal of …, 2017 - atsjournals.org
Background: Airway remodeling (AR) is a prominent feature of asthma and other obstructive
lung diseases that is minimally affected by current treatments. The goals of this Official …
lung diseases that is minimally affected by current treatments. The goals of this Official …
Airway smooth muscle remodeling is a dynamic process in severe long-standing asthma
M Hassan, T Jo, PA Risse, B Tolloczko… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: The origin of the excess airway smooth muscle in asthma and when in the
course of the disease it is acquired are uncertain. OBJECTIVES: We examined the relative …
course of the disease it is acquired are uncertain. OBJECTIVES: We examined the relative …
Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype
PA Risse, T Jo, F Suarez, N Hirota… - … of Physiology-Lung …, 2011 - journals.physiology.org
IL-13 is an important mediator of allergen-induced airway hyperresponsiveness. This Th2
cytokine, produced by activated T cells, mast cells, and basophils, has been described to …
cytokine, produced by activated T cells, mast cells, and basophils, has been described to …
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma
G Ijpma, L Kachmar, OS Matusovsky… - American journal of …, 2015 - atsjournals.org
Rationale: Airway smooth muscle (ASM) plays a key role in airway hyperresponsiveness
(AHR) but it is unclear whether its contractility is intrinsically changed in asthma. Objectives …
(AHR) but it is unclear whether its contractility is intrinsically changed in asthma. Objectives …
Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle
D Jackson, J Walum, P Banerjee, BW Lewis… - Respiratory …, 2022 - Springer
Background Corticosteroids remain a key therapy for treating children with asthma. Patients
with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly …
with severe asthma are insensitive, resistant, or refractory to corticosteroids and have poorly …
5-Aza-2′-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching
Y Ning, H Huang, Y Dong, Q Sun, W Zhang, W Xu… - Archives of …, 2013 - Springer
Airway smooth muscle (ASM) cell phenotypic switching played an important role in airway
remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell …
remodeling in asthma. In vitro platelet-derived growth factor (PDGF) induced ASM cell …