Owing to rising levels of greenhouse gases in our atmosphere and oceans, climate change
poses significant environmental, economic, and social challenges globally. Technologies …

Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron
donor in all organisms. It provides the reducing power that drives numerous anabolic …

Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …

Abstract eQuilibrator (equilibrator. weizmann. ac. il) is a database of biochemical equilibrium
constants and Gibbs free energies, originally designed as a web-based interface. While the …

Genome-scale network reconstructions have helped uncover the molecular basis of
metabolism. Here we present Recon3D, a computational resource that includes three …

Genome-scale metabolic models are instrumental in uncovering operating principles of
cellular metabolism, for model-guided re-engineering, and unraveling cross-feeding in …

Genome-scale metabolic models derived from human gut metagenomic data can be used
as a framework to elucidate how microbial communities modulate human metabolism and …

A multitude of factors contribute to complex diseases and can be measured with 'omics'
methods. Databases facilitate data interpretation for underlying mechanisms. Here, we …

The capture of CO2 by carboxylases is key to sustainable biocatalysis and a carbon-neutral
bio-economy, yet currently limited to few naturally existing enzymes. Here, we developed …

Synthetic biology offers the opportunity to build solutions for improved capture and
conversion of carbon dioxide (CO2) that outcompete those evolved by nature. Here we …