Enteric glial biology, intercellular signalling and roles in gastrointestinal disease

L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

Cellular and molecular architecture of the intestinal stem cell niche

N McCarthy, J Kraiczy, RA Shivdasani - Nature cell biology, 2020 - nature.com
Intestinal stem and progenitor cells replicate and differentiate in distinct compartments,
influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals …

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

MJ Workman, MM Mahe, S Trisno, HM Poling… - Nature medicine, 2017 - nature.com
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development …

The enteric nervous system in gastrointestinal disease etiology

AM Holland, AC Bon-Frauches, D Keszthelyi… - Cellular and Molecular …, 2021 - Springer
A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

Enteric nervous system development: what could possibly go wrong?

M Rao, MD Gershon - Nature Reviews Neuroscience, 2018 - nature.com
The gastrointestinal tract contains its own set of intrinsic neuroglial circuits—the enteric
nervous system (ENS)—which detects and responds to diverse signals from the …

Enteric nervous system development: A crest cell's journey from neural tube to colon

N Nagy, AM Goldstein - Seminars in cell & developmental biology, 2017 - Elsevier
The enteric nervous system (ENS) is comprised of a network of neurons and glial cells that
are responsible for coordinating many aspects of gastrointestinal (GI) function. These cells …

[HTML][HTML] Morphogenesis and maturation of the embryonic and postnatal intestine

AM Chin, DR Hill, M Aurora, JR Spence - Seminars in cell & developmental …, 2017 - Elsevier
The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion,
and a major site of host immunity. In order to keep up with daily demands, the intestine has …

Interactions between the microbiota and enteric nervous system during gut-brain disorders

S Fried, E Wemelle, PD Cani, C Knauf - Neuropharmacology, 2021 - Elsevier
For the last 20 years, researchers have focused their intention on the impact of gut
microbiota in healthy and pathological conditions. This year (2021), more than 25,000 …

Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance

LY Hung, KG Margolis - Nature Reviews Gastroenterology & …, 2024 - nature.com
Autism spectrum disorders (ASDs) are recognized as central neurodevelopmental disorders
diagnosed by impairments in social interactions, communication and repetitive behaviours …

Development, diversity, and neurogenic capacity of enteric glia

W Boesmans, A Nash, KR Tasnády, W Yang… - Frontiers in Cell and …, 2022 - frontiersin.org
Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the
“support” cells of the enteric nervous system, studies over the past 20 years have unveiled a …