Combining copper and zinc into a biosensor for anti-chemoresistance and achieving osteosarcoma therapeutic efficacy
Due to its built-up chemoresistance after prolonged usage, the demand for replacing
platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for …
platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for …
Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: a review on recent advances and future challenges
Y Jiang, C Yan, M Li, S Chen, Z Chen, L Yang… - International Journal of …, 2024 - Elsevier
Cancer, caused by uncontrolled proliferation of abnormal cells, has long been a global
public health issue. For decades, natural products have been proven to be an essential …
public health issue. For decades, natural products have been proven to be an essential …
Recent advances in small molecule and peptide inhibitors of glucose-regulated protein 78 for cancer therapy
W Guo, M Wang, Z Yang, D Liu, B Ma, Y Zhao… - European Journal of …, 2023 - Elsevier
Abstract Glucose-regulated protein 78 (GRP78) is one of key endoplasmic reticulum (ER)
chaperone proteins that regulates the unfolded protein response (UPR) to maintain ER …
chaperone proteins that regulates the unfolded protein response (UPR) to maintain ER …
Electrochemical Synthesis of New Isoxazoles and Triazoles Tethered with Thiouracil Base as Inhibitors of Histone Deacetylases in Human Breast Cancer Cells
D Vishwanath, Z Xi, A Ravish, A Mohan, S Basappa… - Molecules, 2023 - mdpi.com
Histone deacetylases (HDACs) are an attractive drug target for the treatment of human
breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being used in preclinical …
breast cancer (BC), and therefore, HDAC inhibitors (HDACis) are being used in preclinical …
Functional roles of CD133: more than stemness associated factor regulated by the microenvironment
AP Moreno-Londoño, M Robles-Flores - Stem Cell Reviews and Reports, 2024 - Springer
CD133 protein has been one of the most used surface markers to select and identify cancer
cells with stem-like features. However, its expression is not restricted to tumoral cells; it is …
cells with stem-like features. However, its expression is not restricted to tumoral cells; it is …
CAMSAP2 enhances lung cancer cell metastasis by mediating RASAL2 degradation
N Singharajkomron, V Yodsurang, V Limprasutr… - Life Sciences, 2024 - Elsevier
Aims Cancer metastasis significantly contributes to mortality in lung cancer patients.
Calmodulin-regulated spectrin-associated protein family member 2 (CAMSAP2) plays a …
Calmodulin-regulated spectrin-associated protein family member 2 (CAMSAP2) plays a …
HDAC6 Enhances Endoglin Expression through Deacetylation of Transcription Factor SP1, Potentiating BMP9-Induced Angiogenesis
C Sun, K Xie, L Yang, S Cai, M Wang, Y Zhu, B Tao… - Cells, 2024 - mdpi.com
Histone deacetylase 6 (HDAC6) plays a crucial role in the acetylation of non-histone
proteins and is notably implicated in angiogenesis, though its underlying mechanisms were …
proteins and is notably implicated in angiogenesis, though its underlying mechanisms were …
Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic
options and expensive/burdensome drug discovery processes. Utilizing genomic-data …
options and expensive/burdensome drug discovery processes. Utilizing genomic-data …
Mutation of the SUMOylation site of Aurora-B disrupts spindle formation and chromosome alignment in oocytes
SS Chen, L Li, B Yao, JL Guo, PS Lu, HL Zhang… - Cell Death …, 2024 - nature.com
Aurora-B is a kinase that regulates spindle assembly and kinetochore-microtubule (KT-MT)
attachment during mitosis and meiosis. SUMOylation is involved in the oocyte meiosis …
attachment during mitosis and meiosis. SUMOylation is involved in the oocyte meiosis …
Inhibition of HDAC6 elicits anticancer effects on head and neck cancer cells through Sp1/SOD3/MKP1 signaling axis to downregulate ERK phosphorylation
R Kausar, NTT Nguyen, TPH Le, JH Kim, SY Lee - Cellular Signalling, 2025 - Elsevier
Oxidative stress caused by reactive oxygen species (ROS) and superoxides is linked to
various cancer-related biological events. Extracellular superoxide dismutase (SOD3), an …
various cancer-related biological events. Extracellular superoxide dismutase (SOD3), an …