The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …

The most common genetic risk factors for Parkinson's disease (PD) are a set of
heterozygous mutant (MT) alleles of the GBA1 gene that encodes β-glucocerebrosidase …

Cells rely on surveillance systems such as autophagy to handle protein alterations and
organelle damage. Dysfunctional autophagy, an evolutionarily conserved cellular …

A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for
degradation through autophagy. Here, we focus on two autophagic pathways, the …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …

All cellular proteins undergo continuous synthesis and degradation. This permanent
renewal is necessary to maintain a functional proteome and to allow rapid changes in levels …

Lysosomes, single-membrane organelles defined by a uniquely strong acidic lumenal pH
and high content of acid hydrolases, are the shared degradative compartments of the …