Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates

L Meng, S Mao, J Lin - … of the National Academy of Sciences, 2024 - National Acad Sciences
Many biomolecular condensates, including transcriptional condensates, are formed in
elastic mediums. In this work, we study the nonequilibrium condensate dynamics in a …

Theory of elastic microphase separation

Y Qiang, C Luo, D Zwicker - arXiv preprint arXiv:2307.06136, 2023 - arxiv.org
Elastic microphase separation refers to equilibrium patterns that form by phase separation in
elastic gels. Recent experiments revealed a continuous phase transition from the …

Nonlocal Elasticity Yields Equilibrium Patterns in Phase Separating Systems

Y Qiang, C Luo, D Zwicker - Physical Review X, 2024 - APS
Recent experiments demonstrated the emergence of regular mesoscopic patterns when
liquid droplets form in an elastic gel after cooling. These patterns appeared via a continuous …

Indissoluble biomolecular condensates via elasticity

L Meng, J Lin - Physical Review Research, 2023 - APS
While biomolecular condensates are often liquidlike, many experiments found that
condensates also exhibit solidlike behaviors, making them indissoluble in conditions liquid …

Criticality enhances the reinforcement of disordered networks by rigid inclusions

JL Shivers, J Feng, FC MacKintosh - arXiv preprint arXiv:2407.19563, 2024 - arxiv.org
The mechanical properties of biological materials are spatially heterogeneous. Typical
tissues are made up of a spanning fibrous extracellular matrix in which various inclusions …

Interfacial cavitation

T Henzel, J Nijjer, S Chockalingam, H Wahdat… - PNAS …, 2022 - academic.oup.com
Cavitation has long been recognized as a crucial predictor, or precursor, to the ultimate
failure of various materials, ranging from ductile metals to soft and biological materials …

Ripening, bursting, and synchronization of biomolecular condensates in a heterogeneous elastic medium

L Meng, S Mao, J Lin - bioRxiv, 2023 - biorxiv.org
Biomolecular condensates play a crucial role in regulating gene expression, but their
behavior in chromatin remains poorly understood. Classical theories of phase separation …

Formation and collapse of non-wetting cavities in soft porous media

OW Paulin - 2023 - ora.ox.ac.uk
Various biological and chemical processes lead to the nucleation and growth of non-wetting
fluid bubbles within the pore space of a soft porous medium, such as the formation of gas …