Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

A Khan, M Ikram, JR Hahm, MO Kim - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders have emerged as a serious health issue in the current era.
The most common neurodegenerative disorders are Alzheimer's disease (AD), Parkinson's …

Antioxidant and neuroprotective effects of caffeine against Alzheimer's and Parkinson's disease: Insight into the role of Nrf-2 and A2AR signaling

M Ikram, TJ Park, T Ali, MO Kim - Antioxidants, 2020 - mdpi.com
This paper reviews the results of studies conducted on the role of caffeine in the
management of different neurological disorders, such as Parkinson's disease (PD) and …

Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment

S Qiu, JP Palavicini, J Wang, NS Gonzalez… - Molecular …, 2021 - Springer
Background Human genetic association studies point to immune response and lipid
metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer's …

Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ142-Induced Alzheimer's Disease

S Ahmad, MH Jo, M Ikram, A Khan, MO Kim - International Journal of …, 2021 - mdpi.com
The current study was undertaken to unveil the protective effects of Luteolin, a natural
flavonoid, against amyloid-beta (Aβ1–42)-induced neuroinflammation, amyloidogenesis …

Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential

DJ Vesga-Jiménez, C Martin, GE Barreto… - International journal of …, 2022 - mdpi.com
One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …

[HTML][HTML] TLR4 targeting as a promising therapeutic strategy for Alzheimer disease treatment

Y Zhou, Y Chen, C Xu, H Zhang, C Lin - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer disease (AD) is a devastating neurodegenerative disorder characterized by
extracellular accumulation of amyloid-beta and formation of intracellular neurofibrillary …

Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

K Thapa, H Khan, U Sharma, AK Grewal, TG Singh - Life Sciences, 2021 - Elsevier
Aims Poly (ADP-ribose) polymerase-(PARP)-1 is predominantly triggered by DNA damage.
Overexpression of PARP-1 is known for its association with the pathogenesis of several …

Fisetin rescues the mice brains against D-galactose-induced oxidative stress, neuroinflammation and memory impairment

S Ahmad, A Khan, W Ali, MH Jo, J Park… - Frontiers in …, 2021 - frontiersin.org
Herein, we have evaluated the protective potentials of Fisetin against d-galactose-induced
oxidative stress, neuroinflammation, and memory impairment in mice. d-galactose (D-gal) …

Dietary nutrition for neurological disease therapy: Current status and future directions

XY Mao, XX Yin, QW Guan, QX Xia, N Yang… - Pharmacology & …, 2021 - Elsevier
Adequate food intake and relative abundance of dietary nutrients have undisputed effects on
the brain function. There is now substantial evidence that dietary nutrition aids in the …

Alpha-linolenic acid impedes cadmium-induced oxidative stress, neuroinflammation, and neurodegeneration in mouse brain

SI Alam, MW Kim, FA Shah, K Saeed, R Ullah, MO Kim - Cells, 2021 - mdpi.com
Alpha-Linolenic acid (ALA), an omega-3 polyunsaturated fatty acid, is extracted from plant
sources and has been shown to be one of the anti-inflammatory and antioxidant agents …