Decoding post-translational modification crosstalk with proteomics
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …
transduce signals and respond to perturbations. PTMs expand protein functionality and …
The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
Towards a structurally resolved human protein interaction network
Cellular functions are governed by molecular machines that assemble through protein-
protein interactions. Their atomic details are critical to studying their molecular mechanisms …
protein interactions. Their atomic details are critical to studying their molecular mechanisms …
A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming
INTRODUCTION MicroRNAs (miRNAs) are a class of highly conserved small regulatory
RNAs. After loading into Argonaute (AGO) proteins, miRNAs promote the degradation and …
RNAs. After loading into Argonaute (AGO) proteins, miRNAs promote the degradation and …
The functional landscape of the human phosphoproteome
Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
[HTML][HTML] Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling
Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
A million peptide motifs for the molecular biologist
A molecular description of functional modules in the cell is the focus of many high-
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …
Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation
Cross-talk between different types of post-translational modifications on the same protein
molecule adds specificity and combinatorial logic to signal processing, but it has not been …
molecule adds specificity and combinatorial logic to signal processing, but it has not been …
Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells
The posttranslational modification of proteins by arginine methylation is functionally
important, yet the breadth of this modification is not well characterized. Using high-resolution …
important, yet the breadth of this modification is not well characterized. Using high-resolution …